Bone matrix collagen, is one of the major contributors to bone quality. No studies have\nexamined how bone quality affects the results of bone transplantation. Collagen cross-links (CCL)\nare the key factor in collagen properties. The purpose was to investigate the influences of CCL for\nboth grafted bone and recipient site bone on the success of bone augmentation. Four-week-old\nmale Wister rats (n = 54) were divided into control and test groups. Control and test groups equally\nsub-divided into donors and recipients. An additional six rats were used to characterize bone at\nday zero. Test groups received 0.2% beta-aminoproperionitrile (BAPN) for 4 weeks as CCL\ninhibitor. Animals were further divided into donor and recipient groups. The transplanted bone\nchips integrated with host bone by 25% more in CCL-deficient animals compared to control.\nHowever, no difference in cortical thickness among all conditions. CCL-deficient transplanted bone\ndid not show any extra signs of osteocyte apoptosis, while sclerostin expression was comparable to\nthat in control. The host periosteum of CCL-deficient animals showed higher cellular activity, as\nwell as higher bone quantity and osteoclast activity. Collagen cross-links deficiency in host bone\nmight accelerate the incorporation of grafted bone. effect. Incorporation of the bone grafts appears\nto depend mainly on host condition rather than graft condition.
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